Use the biochemical principles we have learned throughout the course to develop and present a poster that explains the function of a biomolecule (or biomolecular complex), as well as its role in human disease.
Friday, Dec. 10, 10am - 12 pm: Poster presentation!
A structural representation of the molecule or complex, clearly identifying residues/structural features important to its function (active site, binding, etc.) and pathology (mutations, modification sites, etc.)
At least one figure with data reporting on the molecule's biochemical function, ideally under normal and disease-associated conditions (e.g., enzyme kinetics, binding affinity measurements)
A diagram depicting the biological process in which the molecule participates, highlighting (as possible) the features relevant to the molecule's normal role and, where possible, what is altered in the disease and through treatment/intervention
A section highlighting the human aspect of the patient experience, describing symptoms, diagnosis and treatment of the condition
Relevant connections and additional information that enhance the story
Where appropriate, concise bullet points that summarize key messages
References to at least 2 literature reviews and 3 primary-literature articles
For some potentially helpful resources, visit the "Online Resources" tab.
Maximize what you can tell with the figures using labels on the figures and bullet points to replace narrative text.
Minimize extraneous information that does not pertain to the story—e.g. simplify complicated figures to only include what is relevant.
Conceptualize your own original figures that provide the framework for what the viewer needs to know to follow your story.
Express your creativity and humor, as long as it's appropriate and enhances the flow, clarity and relevance of the information.
When thinking about your molecule’s molecular structure, consider:
Molecule’s name and pdb code
Catalytic and/or binding-site residues
Other functionally important residues
Images you might like to create in a structural image viewer
When thinking about your molecule’s biochemical function consider:
The molecule's normal biochemical functions
The assay(s) used to demonstrate that molecule’s activity
The molecule’s requirements for activity (cofactor, ATP, conditions...)
The molecule’s biochemical interactions (binding partner, substrate, membrane...)
Figures that help to explain/demonstrate these functions
Biochemical data that illuminate the difference between normal and disease conditions
When thinking about your molecule’s biological function consider:
The overall biological process the molecule is involved in
The specific step the molecule is involved in
The pathway’s normal mechanism
The mechanism by which the molecule's impairment affects the pathway
What is still unknown about the molecule’s biological function(s)
When thinking about your molecule’s connection to human disease consider:
Effects/symptoms of the disease
How the condition is diagnosed, in particular, biochemical tests
Risk factors of the disease, if any exist
Cellular and tissue-level effects and the assay(s) used to characterize those effects
Current drugs/treatment: efficacy and side effects
What is still unknown about the physiological/health/disease impact